Improved positioning and detectability of microparticles in droplet microfluidics using two-dimensional acoustophoresis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

We have fabricated a silicon-glass two-phase droplet microfluidic system capable of generating sub 100 μm-sized, ø = (74 ± 2) μm, spherical droplets at rates of up to hundreds of hertz. By implementing a two-dimensional (2D) acoustophoresis particle-positioning method, we show a fourfold improvement in both vertical and lateral particle positioning inside the droplets compared to unactuated operation. The efficiency of the system has been optimized by incorporating aluminum matching layers in the transducer design permitting biocompatible operational temperatures (<37 °C). Furthermore, by using acoustic actuation, (99.8 ± 0.4)% of all encapsulated microparticles can be detected compared to only (79.0 ± 5.1)% for unactuated operation. In our experiments we observed a strong ordering of the microparticles in distinct patterns within the droplet when using 2D acoustophoresis; to explain the origin of these patterns we simulated numerically the fluid flow inside the droplets and compared with the experimental findings.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Uppsala universitet, Historiska institutionen
  • Technical University of Denmark
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Strömningsmekanik och akustik

Nyckelord

Originalspråkengelska
Artikelnummer084002
TidskriftJournal of Micromechanics and Microengineering
Volym27
Utgivningsnummer8
StatusPublished - 2017 jul 20
PublikationskategoriForskning
Peer review utfördJa
EvenemangMicromechanics and Microsystems Europe Conference, 2016 - Cork, Irland
Varaktighet: 2016 jun 282016 aug 30
Konferensnummer: 27

Relaterad forskningsoutput

Anna Fornell, 2018 jun 5, Lund: Department of Biomedical Engineering, Lund university. 134 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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