Improving the reporting quality of intervention trials addressing the inter-individual variability in response to the consumption of plant bioactives: quality index and recommendations

Forskningsoutput: TidskriftsbidragÖversiktsartikel


Purpose: The quality of the study design and data reporting in human trials dealing with the inter-individual variability in response to the consumption of plant bioactives is, in general, low. There is a lack of recommendations supporting the scientific community on this topic. This study aimed at developing a quality index to assist the assessment of the reporting quality of intervention trials addressing the inter-individual variability in response to plant bioactive consumption. Recommendations for better designing and reporting studies were discussed. Methods: The selection of the parameters used for the development of the quality index was carried out in agreement with the scientific community through a survey. Parameters were defined, grouped into categories, and scored for different quality levels. The applicability of the scoring system was tested in terms of consistency and effort, and its validity was assessed by comparison with a simultaneous evaluation by experts’ criteria. Results: The “POSITIVe quality index” included 11 reporting criteria grouped into four categories (Statistics, Reporting, Data presentation, and Individual data availability). It was supported by detailed definitions and guidance for their scoring. The quality index score was tested, and the index demonstrated to be valid, reliable, and responsive. Conclusions: The evaluation of the reporting quality of studies addressing inter-individual variability in response to plant bioactives highlighted the aspects requiring major improvements. Specific tools and recommendations favoring a complete and transparent reporting on inter-individual variability have been provided to support the scientific community on this field.


  • Marina Nikolic
  • Aleksandra Konic Ristic
  • Antonio González-Sarrías
  • Geoffrey Istas
  • Mireia Urpi-Sarda
  • Margherita Dall’Asta
  • Laurent Emmanuel Monfoulet
  • Banu Bayram
  • Maria Rosaria Tumolo
  • Mihail Chervenkov
  • Egeria Scoditti
  • Marika Massaro
  • Noemi Tejera
  • Desislava Abadjieva
  • Karen Chambers
  • Irena Krga
  • Francisco A. Tomás-Barberán
  • Christine Morand
  • Rodrigo Feliciano
  • Rocío García-Villalba
  • Mar Garcia-Aloy
  • Pedro Mena
Enheter & grupper
Externa organisationer
  • University College Dublin
  • CSIC Centro de Edafología y Biología Aplicada del Segura (CEBAS)
  • King's College London
  • University of Barcelona
  • Carlos III Health Institute
  • University of Parma
  • University of Auvergne
  • Bulgarian Academy of Sciences
  • University of Belgrade
  • University of Health Sciences, Turkey
  • Institute for Research on Population and Social Policies (CNR-IRPPS)
  • University of Forestry, Sofia
  • CNR Institute of Clinical Physiology (IFC)
  • University of East Anglia
  • Institute of Food Research
  • Heinrich Heine University Düsseldorf

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Näringslära


Sidor (från-till)49-64
Antal sidor16
TidskriftEuropean Journal of Nutrition
Utgåva nummerS2
StatusPublished - 2019 nov 1
Peer review utfördJa