In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.

Detaljer

Författare
Externa organisationer
  • Örebro University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Anestesi och intensivvård

Nyckelord

Originalspråkengelska
Sidor (från-till)233-239
TidskriftScandinavian Journal of Clinical & Laboratory Investigation
Volym48
Utgivningsnummer3
StatusPublished - 1988
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa

Related projects

Ulf Schött

1990/05/012019/03/31

Projekt: Forskning

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