In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Bibtex

@article{80182be5c4274ddd94d4b46810ab61b3,
title = "In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.",
abstract = "The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.",
keywords = "6-Ketoprostaglandin F1 alpha: analogs & derivatives, 6-Ketoprostaglandin F1 alpha: urine, Hip Prosthesis: adverse effects, Thrombosis: etiology, Thromboxane B2: analogs & derivatives, Thromboxane B2: urine",
author = "O Vesterqvist and Ulf Sch{\"o}tt and O Bers{\'e}us and K Axelsson and K Gr{\'e}en",
year = "1988",
doi = "10.3109/00365518809167489",
language = "English",
volume = "48",
pages = "233--239",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "1502-7686",
publisher = "Informa Healthcare",
number = "3",

}