In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.

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In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty. / Vesterqvist, O; Schött, Ulf; Berséus, O; Axelsson, K; Gréen, K.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 48, Nr. 3, 1988, s. 233-239.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - In vivo production of thromboxane and prostacyclin in patients following total hip arthroplasty.

AU - Vesterqvist, O

AU - Schött, Ulf

AU - Berséus, O

AU - Axelsson, K

AU - Gréen, K

PY - 1988

Y1 - 1988

N2 - The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.

AB - The in vivo production of thromboxane and prostacyclin was studied by measurements of their major urinary metabolites in eight patients undergoing total hip arthroplasty. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha. The excretion of these metabolites increased about 10-fold during the intra and immediate postoperative period and 4 days after surgery was still higher than during the preoperative period. The increased thromboxane formation reflects probable activation of platelets whereas the increased prostacyclin could be part of a vascular defense against induced thrombotic activity. These findings may have pathophysiological implications.

KW - 6-Ketoprostaglandin F1 alpha: analogs & derivatives

KW - 6-Ketoprostaglandin F1 alpha: urine

KW - Hip Prosthesis: adverse effects

KW - Thrombosis: etiology

KW - Thromboxane B2: analogs & derivatives

KW - Thromboxane B2: urine

U2 - 10.3109/00365518809167489

DO - 10.3109/00365518809167489

M3 - Article

VL - 48

SP - 233

EP - 239

JO - Scandinavian Journal of Clinical & Laboratory Investigation

T2 - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 1502-7686

IS - 3

ER -