Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients <80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both P<0.001), followed by sex (P=0.0135) and a karyotype including -7/del(7q) (P=0.048).

Detaljer

Författare
  • Vladimir Lazarevic
  • Ann-sofi Hörstedt
  • Erik Johansson
  • P Antunovic
  • R Billström
  • A Derolf
  • E Hulegårdh
  • S Lehmann
  • L Möllgård
  • C Nilsson
  • Stefan Peterson
  • D Stockelberg
  • B Uggla
  • L Wennström
  • A Wahlin
  • M Höglund
  • Gunnar Juliusson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)e188
TidskriftBlood Cancer Journal
Volym4
UtgivningsnummerFeb 28
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa

Nedladdningar

Ingen tillgänglig data

Relaterad forskningsoutput

Lazarevic, V., 2015, Stam Cells Centrum (SCC). 56 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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