Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience.

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Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience. / Lazarevic, Vladimir; Hörstedt, Ann-sofi; Johansson, Bertil; Antunovic, P; Billström, R; Derolf, A; Hulegårdh, E; Lehmann, S; Möllgård, L; Nilsson, C; Peterson, Stefan; Stockelberg, D; Uggla, B; Wennström, L; Wahlin, A; Höglund, M; Juliusson, Gunnar.

I: Blood Cancer Journal, Vol. 4, Nr. Feb 28, 2014, s. e188.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Lazarevic, V, Hörstedt, A, Johansson, B, Antunovic, P, Billström, R, Derolf, A, Hulegårdh, E, Lehmann, S, Möllgård, L, Nilsson, C, Peterson, S, Stockelberg, D, Uggla, B, Wennström, L, Wahlin, A, Höglund, M & Juliusson, G 2014, 'Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience.', Blood Cancer Journal, vol. 4, nr. Feb 28, s. e188. https://doi.org/10.1038/bcj.2014.10

APA

CBE

Lazarevic V, Hörstedt A, Johansson B, Antunovic P, Billström R, Derolf A, Hulegårdh E, Lehmann S, Möllgård L, Nilsson C, Peterson S, Stockelberg D, Uggla B, Wennström L, Wahlin A, Höglund M, Juliusson G. 2014. Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience. Blood Cancer Journal. 4(Feb 28):e188. https://doi.org/10.1038/bcj.2014.10

MLA

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Author

Lazarevic, Vladimir ; Hörstedt, Ann-sofi ; Johansson, Bertil ; Antunovic, P ; Billström, R ; Derolf, A ; Hulegårdh, E ; Lehmann, S ; Möllgård, L ; Nilsson, C ; Peterson, Stefan ; Stockelberg, D ; Uggla, B ; Wennström, L ; Wahlin, A ; Höglund, M ; Juliusson, Gunnar. / Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience. I: Blood Cancer Journal. 2014 ; Vol. 4, Nr. Feb 28. s. e188.

RIS

TY - JOUR

T1 - Incidence and prognostic significance of karyotypic subgroups in older patients with acute myeloid leukemia: the Swedish population-based experience.

AU - Lazarevic, Vladimir

AU - Hörstedt, Ann-sofi

AU - Johansson, Bertil

AU - Antunovic, P

AU - Billström, R

AU - Derolf, A

AU - Hulegårdh, E

AU - Lehmann, S

AU - Möllgård, L

AU - Nilsson, C

AU - Peterson, Stefan

AU - Stockelberg, D

AU - Uggla, B

AU - Wennström, L

AU - Wahlin, A

AU - Höglund, M

AU - Juliusson, Gunnar

PY - 2014

Y1 - 2014

N2 - The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients <80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both P<0.001), followed by sex (P=0.0135) and a karyotype including -7/del(7q) (P=0.048).

AB - The Swedish population-based acute myeloid leukemia registry contains data from 3251 patients (excluding acute promyelocytic leukemia) diagnosed between 1997 and 2006. Informative cytogenetic data from 1893 patients were retrospectively added, including 1054 patients aged between 60 and 79 years. Clonal abnormalities were found in 57% of the informative karyotypes. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotypes were more common in older patients. Loss of 5q, 7q and 17p often occurred together within MK. Patients with 5 chromosome abnormalities had worse overall survival than those with fewer abnormalities or normal karyotype in all age groups. Loss of 5q, 7q and/or 17p had, in contrast to MK, a further negative impact on survival. Multivariable Cox regression analyses on risk factors in patients <80 years with cytogenetic abnormalities and intensive treatment revealed that age and performance status had the most significant impact on survival (both P<0.001), followed by sex (P=0.0135) and a karyotype including -7/del(7q) (P=0.048).

U2 - 10.1038/bcj.2014.10

DO - 10.1038/bcj.2014.10

M3 - Article

VL - 4

SP - e188

JO - Blood Cancer Journal

T2 - Blood Cancer Journal

JF - Blood Cancer Journal

SN - 2044-5385

IS - Feb 28

ER -