Increase of bikunin and alpha1-microglobulin concentrations in urine of rats during pregnancy is due to decreased tubular reabsorption

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine increased 3-fold towards the end of the pregnancy, whereas those of albumin and orosomucoid did not. There were no significant changes in either the bikunin/alpha1-microglobulin mRNA level or the concentrations of the two proteins in serum. These findings imply that the synthesis and the clearance rates of bikunin and alpha1-microglobulin are normal during pregnancy but that the tubular reabsorption of these proteins is decreased.

Detaljer

Författare
  • Anna M Blom
  • Cecilia Falkenberg
  • Mats Sjöquist
  • Ulf J Eriksson
  • Bo Åkerström
  • Erika Fries
Enheter & grupper
Externa organisationer
  • Uppsala universitet, Historiska institutionen
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
  • Cell- och molekylärbiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)198-202
Antal sidor5
TidskriftBiochimica et biophysica acta
Volym1361
Utgivningsnummer2
StatusPublished - 1997 aug 22
PublikationskategoriForskning
Peer review utfördJa