Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

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T1 - Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.

AU - Mahmutovic Persson, Irma

AU - Akbarshahi, Hamid

AU - Menzel, Mandy

AU - Brandelius, Angelica

AU - Uller, Lena

PY - 2016

Y1 - 2016

N2 - Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

AB - Exacerbations of asthma caused by respiratory viral infections are serious conditions in need of novel treatment. To this end animal models of asthma exacerbations are warranted. We have shown that dsRNA challenges or rhinoviral infection produce exacerbation effects in mice with ovalbumin (OVA)-induced allergic asthma. However, house dust mite (HDM) is a more human asthma-relevant allergen than OVA. We thus hypothesised that dsRNA challenges in mice with HDM-induced experimental asthma would produce important translational features of asthma exacerbations.

U2 - 10.1186/s12967-016-0808-x

DO - 10.1186/s12967-016-0808-x

M3 - Article

VL - 14

JO - Journal of Translational Medicine

T2 - Journal of Translational Medicine

JF - Journal of Translational Medicine

SN - 1479-5876

IS - 1

M1 - 52

ER -