Increased survival with mechanical ventilation in post-tuberculosis patients with the combination of respiratory failure and chest wall deformity

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Abstract

Background Patients who have suffered from tuberculosis are at risk of respiratory failure with hypercapnea from chest wall deformity and hypoxia from pulmonary sequelae. The combination of hypercapnea and hypoxia justifies both mechanical ventilation and oxygen therapy as treatment options. We aimed to study which treatment mode is associated with the best survival in patients with the combination of respiratory failure and chest wall deformity from tuberculosis. Methods Swedish patients starting oxygen therapy or mechanical ventilation between 1996 and 2004 due to the combination of respiratory failure and chest wall deformity from tuberculosis were eligible for conclusion. They were followed prospectively until October 2006, with death as the primary outcome. Results A cohort of 188 patients was included. Eighty-five received mechanical ventilation and 103 received oxygen therapy alone. No patients were excluded and none was lost to follow-up. Mechanical ventilation was associated with a significantly better survival than oxygen therapy alone, even after adjustments for age, gender, concomitant respiratory disease, blood gas tensions and vital capacity, with an adjusted hazard risk of death of 0.35 (95% CI 0.17-0.70). Conclusion Patients with the combination of respiratory failure and chest wall deformity from tuberculosis had a significantly better survival when treated with home mechanical ventilation than with long-term oxygen therapy alone. We recommend home mechanical ventilation with or without supplementary oxygen as the first choice of treatment for these patients.

Detaljer

Författare
  • Linda Jäger
  • Karl A Franklin
  • Bengt Midgren
  • Kerstin Löfdahl
  • Kerstin Ström
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi

Nyckelord

Originalspråkengelska
Sidor (från-till)156-160
TidskriftChest
Volym133
Utgåva nummer1
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa