Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan. (Am Heart J 2010; 159: 730-736.e2.)

Detaljer

Författare
  • Matthias W. Lorenz
  • Horst Bickel
  • Michiel L. Bots
  • Monique M. B. Breteler
  • Alberico L. Catapano
  • Moise Desvarieux
  • Bernhard Iglseder
  • Stein Harald Johnsen
  • Michal Juraska
  • Stefan Kiechl
  • Ellisiv B. Mathiesen
  • Giuseppe D. Norata
  • Liliana Grigore
  • Joseph Polak
  • Holger Poppert
  • Maria Rosvall
  • Tatjana Rundek
  • Ralph L. Sacco
  • Dirk Sander
  • Matthias Sitzer
  • Helmuth Steinmetz
  • Eva Stensland
  • Johann Willeit
  • Jacqueline Witteman
  • David Yanez
  • Simon G. Thompson
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Originalspråkengelska
Sidor (från-till)730-U25
TidskriftAmerican Heart Journal
Volym159
Utgåva nummer5
StatusPublished - 2010
PublikationskategoriForskning
Peer review utfördJa