Inflammation and cholesterol

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Atherosclerosis develops as a result of a chronic arterial inflammation and intimal Fibrosis. The disease represents in many respects a vascular repair process activated in response to injury caused by toxic breakdown products of aggregated and oxidized lipoproteins. The initial response of the artery involves expression of adhesion molecules and recruitment of leukocytes. Degenerated lipoproteins are removed front the extracellular space by macrophages. If lipoproteins continue to I process becomes chronic and accumulate. the inflammatory cytokines stimulate smooth muscle to migrate into the intima. These cells proliferate and form an atherosclerotic plaque. Plaque cell death and inflammation in response to oxidized lipids and other toxic factors May Cause plaques to rupture.

Detaljer

Författare
  • Jan Nilsson
  • Mikko Ares
  • Marie Lindholm
  • Gunilla Nordin Fredrikson
  • Stefan Jovinge
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi

Nyckelord

Originalspråkengelska
Sidor (från-till)A18-A25
TidskriftEuropean Heart Journal Supplements
Volym4
Utgåva nummerSuppl A
StatusPublished - 2002
PublikationskategoriForskning
Peer review utfördJa