Influence of polar co-solutes and salt on the hydration of lipid membranes

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The influence of the co-solutes TMAO, urea, and NaCl on the hydration repulsion between lipid membranes is investigated in a combined experimental/simulation approach. Pressure-hydration curves obtained via sorption experiments reveal that the repulsion significantly increases when the membranes are loaded with co-solutes, most strongly for TMAO. As a result, the co-solutes retain additional water molecules and therefore provide membranes with a fluid and more physiological environment. The experimental data are quantitatively reproduced in complementary solvent-explicit atomistic molecular dynamics simulations, which yield the chemical potential of water. Simulation analysis reveals that the additional repulsion arises from the osmotic pressure generated by the co-solutes, an effect which is maximal for TMAO, due to its unfavorable interactions with the lipid headgroup layer and its extraordinarily high osmotic coefficient.


Enheter & grupper
Externa organisationer
  • Free University of Berlin
  • University Grenoble Alpes
  • Max Planck Institute of Colloids and Interfaces

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biofysik
Sidor (från-till)16989-17000
Antal sidor12
TidskriftPhysical Chemistry Chemical Physics
Utgåva nummer31
StatusPublished - 2019
Peer review utfördJa