Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma

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title = "Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma",
abstract = "Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result, novel treatment strategies are needed for relapse and refractory neuroblastoma patients. Here, we found that high expression of Mps1 kinase (mitotic kinase Monopolar Spindle 1) was associated with relapse-free neuroblastoma patient outcomes and poor overall survival. Silencing and inhibition of Mps1 in neuroblastoma or PDX-derived cells promoted cell apoptosis via the caspase-dependent mitochondrial apoptotic pathway. The mechanism of cell death upon Mps1 inhibition was dependent on the polyploidization/aneuploidization of the cells before undergoing mitotic catastrophe. Furthermore, tumour growth retardation was confirmed in a xenograft mouse model after Mps1-inhibitor treatment. Altogether, these results suggest that Mps1 expression and inhibition can be considered as a novel prognostic marker as well as a therapeutic strategy for the treatment of high-risk neuroblastoma patients.",
author = "{Simon Serrano}, Sonia and Wondossen Sime and Yasmin Abassi and Ren{\'e}e Daams and Ramin Massoumi and Mohamed Jema{\`a}",
note = "These authors jointly supervised this work: Ramin Massoumi and Mohamed Jema{\`a}.",
year = "2020",
month = jul,
day = "20",
doi = "10.1038/s41598-020-68829-y",
language = "English",
volume = "10",
pages = "11997",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",