In-Source Decay Causes Artifacts in SELDI-TOF MS Spectra.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

SELDI-TOF MS is a mass spectrometric technique which has been extensively used for biomarker discovery. In this study, we show that in-source decay is an important source for the generation of additional spectral peaks with this technique, both for pure proteins and proteins in serum samples. Thus, SELDI-TOF MS could be used to gain sequence information from proteins, but the results also question the uncritical use of SELDI-TOF MS as a general method for the detection of biomarkers.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)1609-1614
TidskriftJournal of Proteome Research
Volym6
Utgivningsnummer4
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa