Instantaneous Wave-Free Ratio versus Fractional Flow Reserve guided intervention (iFR-SWEDEHEART): Rationale and design of a multicenter, prospective, registry-based randomized clinical trial.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Instantaneous wave-free ratio (iFR) is a new hemodynamic resting index for assessment of coronary artery stenosis severity. iFR uses high frequency sampling to calculate a gradient across a coronary lesion during a period of diastole. The index has been tested against fractional flow reserve (FFR) and found to have an overall classification agreement of 80% to 85%. Whether the level of disagreement is clinically relevant is unknown. Clinical outcome data on iFR are scarce. This study is a registry-based randomized clinical trial, which is a novel strategy using health quality registries as on-line platforms for randomization, case record forms, and follow-up.


  • Matthias Götberg
  • Evald H Christiansen
  • Ingibjörg Gudmundsdottir
  • Lennart Sandhall
  • Elmir Omerovic
  • Stefan K James
  • David Erlinge
  • Ole Fröbert
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Sidor (från-till)945-950
TidskriftAmerican Heart Journal
Utgåva nummer5
StatusPublished - 2015
Peer review utfördJa