Interaction between amphiphilic peptides and phospholipid membranes

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Interaction between amphiphilic peptides and phospholipid membranes. / Stromstedt, Adam A.; Ringstad, Lovisa; Schmidtchen, Artur; Malmsten, Martin.

I: Current Opinion in Colloid & Interface Science, Vol. 15, Nr. 6, 2010, s. 467-478.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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TY - JOUR

T1 - Interaction between amphiphilic peptides and phospholipid membranes

AU - Stromstedt, Adam A.

AU - Ringstad, Lovisa

AU - Schmidtchen, Artur

AU - Malmsten, Martin

PY - 2010

Y1 - 2010

N2 - This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing (C) 2010 Elsevier Ltd All rights reserved

AB - This brief review aims at providing some illustrative examples on the interaction between amphiphilic peptides and phospholipid membranes an area of significant current interest Focusing on antimicrobial peptides factors affecting peptide-membrane interactions are addressed including effects of peptide length charge hydrophobicity secondary structure and topology Effects of membrane composition are also illustrated including effects of membrane charge nature of the polar headgroup and presence of cholesterol and other sterols Throughout novel insights on the importance of peptide adsorption density on membrane stability are emphasized as is the correlation between peptide adsorption peptide induced leakage in model liposome systems peptide-induced lysis of bacteria and bacteria killing (C) 2010 Elsevier Ltd All rights reserved

KW - Liposome

KW - Bacteria

KW - AMP

KW - Antimicrobial peptide

KW - Membrane

U2 - 10.1016/j.cocis.2010.05.006

DO - 10.1016/j.cocis.2010.05.006

M3 - Review article

VL - 15

SP - 467

EP - 478

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

SN - 1359-0294

IS - 6

ER -