Interaction of dietary and genetic factors influencing body iron status and risk of type 2 diabetes within the EPIC-InterAct study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


OBJECTIVE Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. RESEARCH DESIGN AND METHODS The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. RESULTS Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (b = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (20.019 [20.043; 0.006]) or transferrin saturation (0.016 [20.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6 V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03). CONCLUSIONS We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.


  • Karina Meidtner
  • Clara Podmore
  • Janine Kröger
  • Yvonne T. Van Der Schouw
  • Benedetta Bendinelli
  • Claudia Agnoli
  • Larraitz Arriola
  • Aurelio Barricarte
  • Heiner Boeing
  • Amanda J. Cross
  • Courtney Dow
  • Kim Ekblom
  • Guy Fagherazzi
  • Marc J. Gunter
  • José María Huerta
  • Paula Jakszyn
  • Mazda Jenab
  • Verena A. Katzke
  • Timothy J. Key
  • Kay Tee Khaw
  • Tilman Kühn
  • Cecilie Kyrø
  • Francesca Romana Mancini
  • Kim Overvad
  • Domenico Palli
  • Salvatore Panico
  • J. Ramón Quirós
  • Miguel Rodríguez-Barranco
  • Carlotta Sacerdote
  • Ivonne Sluijs
  • Magdalena Stepien
  • Anne Tjonneland
  • Rosario Tumino
  • Nita G. Forouhi
  • Stephen J. Sharp
  • Claudia Langenberg
  • Matthias B. Schulze
  • Elio Riboli
  • Nicholas J. Wareham
Enheter & grupper
Externa organisationer
  • German Institute of Human Nutrition
  • German Center for Diabetes Research
  • University of Cambridge
  • University Medical Center Utrecht
  • Cancer Research and Prevention Institute
  • Istituto Nazionale dei Tumori
  • Public Health Division of Gipuzkoa
  • Instituto BIO-Donostia
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Navarre Public Health Institute
  • Health Research Institute of Navarra (IDISNA)
  • Imperial College London
  • INSERM U1018
  • University of Paris-Sud
  • Institut Gustave Roussy
  • Umeå University
  • International Agency for Research on Cancer, World Health Organization
  • Murcia Regional Health Council
  • Catalan Institute of Oncology
  • Ramon Llull University
  • German Cancer Research Centre
  • University of Oxford
  • Danish Cancer Society Research Center
  • Aarhus University
  • Aalborg University
  • University of Naples Federico II
  • Public Health Directorate
  • Instituto de Investigación Biosanitaria de Granada (Granada.ibs)
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • Human Genetic Foundation (HuGeF)
  • Azienda Sanitaria Provinciale di Ragusa
  • L’ Associazione Iblea per la Ricerca Epidemiologica (A.I.R.E.)

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Endokrinologi och diabetes
Sidor (från-till)277-285
TidskriftDiabetes Care
StatusPublished - 2018 feb 1
Peer review utfördJa