Interferon production in glia and glioma cell lines

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Interferon (IF) was produced in glia and glioma cell lines in titers comparable to those produced by human fibroblasts. It was inducible by both Sendai virus and polyriboinosinic:polyribocytidylic acid. "Superinduction" resulted in up to 500-fold-higher titers of IF. The IF appeared to be of the fibroblast type, as revealed by experiments using heat treatment, assay of antiviral activity in heterologous cell lines, and neutralization with specific antisera. Since large amounts of IF may easily be produced with glioma cell lines, such cells may be suitable for mass production of IF.

Detaljer

Författare
  • Inger Larsson
  • Lars-Erik Landström
  • Ebba Larner
  • Erik Lundgren
  • Håkan Miörner
  • Örjan Strannegård
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området
Originalspråkengelska
Sidor (från-till)786-789
TidskriftInfection and Immunity
Volym22
Utgåva nummer3
StatusPublished - 1978
PublikationskategoriForskning
Peer review utfördJa