International comparison of trends in patients commencing renal replacement therapy by primary renal disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Aim: To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD). Methods: Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confidence interval (CI) of the time trends was computed using Joinpoint regression. Results: There was a significant decrease in the incidence of RRT for ESRD due to diabetes mellitus (DM) in Europe (AAPC = −0.9; 95%CI −1.3; −0.5) and to hypertension/renal vascular disease (HT/RVD) in Australia (AAPC = −1.8; 95%CI −3.3; −0.3), Canada (AAPC = −2.9; 95%CI −4.4; −1.5) and Europe (AAPC = −1.1; 95%CI −2.1; −0.0). A decrease or stabilization was observed for glomerulonephritis in all regions and for autosomal dominant polycystic kidney disease (ADPKD) in all regions except for Malaysia and the Republic of Korea. An increase of 5.2–16.3% was observed for DM, HT/RVD and ADPKD in Malaysia and the Republic of Korea. Conclusion: Large international differences exist in the trends in incidence of RRT by primary renal disease. Mapping of these international trends is the first step in defining the causes and successful preventative measures of CKD.


  • Vianda S. Stel
  • Ryan Awadhpersad
  • Maria Pippias
  • Manuel Ferrer-Alamar
  • Patrik Finne
  • Simon D. Fraser
  • James G. Heaf
  • Marc H. Hemmelder
  • Alberto Martínez-Castelao
  • Johan de Meester
  • Runolfur Palsson
  • Friedrich C. Prischl
  • Mårten Segelmark
  • Jamie P. Traynor
  • Rafael Santamaria
  • Anna Varberg Reisæter
  • Ziad A. Massy
  • Kitty J. Jager
Enheter & grupper
Externa organisationer
  • Helsinki University Central Hospital
  • University of Southampton
  • Nefrovisie Foundation
  • National University Hospital of Iceland
  • University of Iceland
  • Scottish Renal Registry
  • Hospital Universitario Reina Sofia
  • Oslo university hospital
  • CHU Ambroise Paré
  • University of Paris-Saclay
  • University of Amsterdam
  • Skåne University Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Urologi och njurmedicin


Sidor (från-till)1064-1076
Utgåva nummer10
StatusPublished - 2019
Peer review utfördJa