Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • University of California
  • Regional Laboratories Region Skåne
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)164-170
Antal sidor7
TidskriftClinical Neuropathology
Volym36
Utgivningsnummer7
StatusPublished - 2017
PublikationskategoriForskning
Peer review utfördJa