Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. / Dahlin, Lars B.; Scherman, Peter; Besjakov, Jack; Lindberg, Eva; Solomon, David A.; Horvai, Andrew E.; Perry, Arie.

I: Clinical Neuropathology, Vol. 36, Nr. 7, 2017, s. 164-170.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case

AU - Dahlin, Lars B.

AU - Scherman, Peter

AU - Besjakov, Jack

AU - Lindberg, Eva

AU - Solomon, David A.

AU - Horvai, Andrew E.

AU - Perry, Arie

PY - 2017

Y1 - 2017

N2 - A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis.

AB - A glomus tumor of uncertain malignant potential is defined as a glomus tumor with some, but not all, criteria for malignancy and without a known metastasis. Here, we present a rare example presenting in the median nerve in a 40-year-old woman with a long history of severely impaired left median nerve function. A large panel of immunohistochemical stains excluded other diagnoses, and the designation of a "uncertain malignant potential" was based on the high proliferative activity, the tumor size and location, and the lack of WHO malignancy criteria such as marked nuclear atypia, necrosis, or atypical mitoses. A BRAF mutation was found in the tumor. Although extremely rare, both benign and malignant glomus tumors may present in large peripheral nerves and should therefore be considered in the differential diagnosis.

KW - BRAF mutation

KW - CT-PET

KW - Intraneural glomus tumor

KW - Median nerve

KW - MRI

KW - Uncertain malignancy

UR - http://www.scopus.com/inward/record.url?scp=85021993618&partnerID=8YFLogxK

U2 - 10.5414/NP300989

DO - 10.5414/NP300989

M3 - Article

VL - 36

SP - 164

EP - 170

JO - Clinical Neuropathology

JF - Clinical Neuropathology

SN - 0722-5091

IS - 7

ER -