Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

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T1 - Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

AU - Welinder, Charlotte

AU - Jirström, Karin

AU - Lehn, Sophie

AU - Nodin, Björn

AU - Marko-Varga, György

AU - Blixt, Ola

AU - Danielsson, Lena

AU - Jansson, Bo

PY - 2016

Y1 - 2016

N2 - A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.

AB - A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.

KW - Medicine

UR - http://www.scopus.com/inward/record.url?scp=84989232417&partnerID=8YFLogxK

U2 - 10.1016/j.heliyon.2016.e00143

DO - 10.1016/j.heliyon.2016.e00143

M3 - Article

VL - 2

JO - Heliyon

JF - Heliyon

SN - 2405-8440

IS - 8

M1 - e00143

ER -