Intravenous Infusions of Purified Alpha-1 Antitripsyn Effectively Controls Symptoms and Reverts Muscle Biopsy Changes in an MZ Alpha-1 Antitripsyn Deficiency and Fibromyalgia Syndrome Patient

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Background: An MZ phenotype alpha-1 antitrypsin [AAT] deficiency and fibromyalgia syndrome [FMS] patient participated in a trial with AAT-intravenous augmentationtherapy [AAT-IV-AT] after failure of conventional therapeutic measures. Three quadricep biopsies were performed at different stages. The first one showed large aggregates of AAT and ubiquitin in myocytes and blood vessels, and moderate muscle atrophy, before AAT-IV-AT. The two remaining biopsies were performed while receiving AAT-IV-AT. Findings: Remarkably good clinical response and histological improvement in the follow-up biopsies. Conclusions: The clinical and histopathological efficacy of AAT-IV-AT evidenced in this patient should open new perspectives of research and management of AAT deficiency and FMS patients.

Detaljer

Författare
  • Ignacio Blanco Blanco
  • Aurora Astudillo
  • Francisco Dominguez Iglesias
  • Sabina Janciauskiene
  • Victoriano Carcaba Fernandez
  • Cesar Gallo Alvaro
  • Hortensia Canto Argiz
  • Frederick Joseph de Serres
  • Enrique Fernandez Bustillo
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reumatologi och inflammation

Nyckelord

Originalspråkengelska
Sidor (från-till)167-172
TidskriftJournal of Musculoskeletal Pain
Volym18
Utgivningsnummer2
StatusPublished - 2010
PublikationskategoriForskning
Peer review utfördJa