Intravenous Infusions of Purified Alpha-1 Antitripsyn Effectively Controls Symptoms and Reverts Muscle Biopsy Changes in an MZ Alpha-1 Antitripsyn Deficiency and Fibromyalgia Syndrome Patient

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Bibtex

@article{ec24f600d0e540efa5e7cd2107740de4,
title = "Intravenous Infusions of Purified Alpha-1 Antitripsyn Effectively Controls Symptoms and Reverts Muscle Biopsy Changes in an MZ Alpha-1 Antitripsyn Deficiency and Fibromyalgia Syndrome Patient",
abstract = "Background: An MZ phenotype alpha-1 antitrypsin [AAT] deficiency and fibromyalgia syndrome [FMS] patient participated in a trial with AAT-intravenous augmentationtherapy [AAT-IV-AT] after failure of conventional therapeutic measures. Three quadricep biopsies were performed at different stages. The first one showed large aggregates of AAT and ubiquitin in myocytes and blood vessels, and moderate muscle atrophy, before AAT-IV-AT. The two remaining biopsies were performed while receiving AAT-IV-AT. Findings: Remarkably good clinical response and histological improvement in the follow-up biopsies. Conclusions: The clinical and histopathological efficacy of AAT-IV-AT evidenced in this patient should open new perspectives of research and management of AAT deficiency and FMS patients.",
keywords = "alpha-1 antitrypsin augmentation therapy, deficiency, alpha-1 antitrypsin, Fibromyalgia syndrome",
author = "{Blanco Blanco}, Ignacio and Aurora Astudillo and {Dominguez Iglesias}, Francisco and Sabina Janciauskiene and {Carcaba Fernandez}, Victoriano and {Gallo Alvaro}, Cesar and {Canto Argiz}, Hortensia and {de Serres}, {Frederick Joseph} and {Fernandez Bustillo}, Enrique",
year = "2010",
doi = "10.3109/10582452.2010.483962",
language = "English",
volume = "18",
pages = "167--172",
journal = "Journal of Musculoskeletal Pain",
issn = "1540-7012",
publisher = "Haworth Press",
number = "2",

}