IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation.

Detaljer

Författare
  • Emma Persson
  • Heli Uronen-Hansson
  • Monika Semmrich
  • Aymeric Rivollier
  • Karin Hägerbrand
  • Jan Marsal
  • Sigurdur Gudjonsson
  • Ulf Håkansson
  • Boris Reizis
  • Knut Kotarsky
  • William Agace
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Immunologi inom det medicinska området
Originalspråkengelska
Sidor (från-till)958-969
TidskriftImmunity
Volym38
Utgivningsnummer5
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa