IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


The role of dendritic cells (DCs) in intestinal immune homeostasis remains incompletely defined. Here we show that mice lacking IRF8 transcription-factor-dependent DCs had reduced numbers of T cells in the small intestine (SI), but not large intestine (LI), including an almost complete absence of SI CD8αβ+ and CD4+CD8αα+ T cells; the latter requiring β8 integrin expression by migratory IRF8 dependent CD103+CD11b- DCs. SI homing receptor induction was impaired during T cell priming in mesenteric lymph nodes (MLN), which correlated with a reduction in aldehyde dehydrogenase activity by SI-derived MLN DCs, and inefficient T cell localization to the SI. These mice also lacked intestinal T helper 1 (Th1) cells, and failed to support Th1 cell differentiation in MLN and mount Th1 cell responses to Trichuris muris infection. Collectively these results highlight multiple non-redundant roles for IRF8 dependent DCs in the maintenance of intestinal T cell homeostasis.


Enheter & grupper
Externa organisationer
  • Technical University of Denmark
  • Ghent University
  • University of Copenhagen
  • University of Manchester
  • Oslo university hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cell- och molekylärbiologi
Sidor (från-till)860-874
Antal sidor15
StatusPublished - 2016 apr 19
Peer review utfördJa

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Müller Luda, K., 2018, Lund: Lund University, Faculty of Medicine. 97 s.

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Demiri, M., 2017, Lund : Lund University, Faculty of Medicine. 69 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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