Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

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Abstract

A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).

Detaljer

Författare
Externa organisationer
  • ACADIA Pharmaceuticals AB
Originalspråkengelska
Sidor (från-till)1771-1773
Antal sidor3
TidskriftOrganic Letters
Volym8
Utgåva nummer9
StatusPublished - 2006 apr 27
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa