Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves: A Swedish cohort study

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Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves : A Swedish cohort study. / Mochalina, Natalia; Isma, Nazim; Svensson, Peter J.; Själander, Anders; Carlsson, Maj; Juhlin, Tord; Wieloch, Mattias.

I: Thrombosis Research, Vol. 158, 01.10.2017, s. 44-48.

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TY - JOUR

T1 - Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves

T2 - A Swedish cohort study

AU - Mochalina, Natalia

AU - Isma, Nazim

AU - Svensson, Peter J.

AU - Själander, Anders

AU - Carlsson, Maj

AU - Juhlin, Tord

AU - Wieloch, Mattias

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011–2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis. Results and conclusion Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37–3.45%) to 1.93% (95% CI 1.54–2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient − 0.08; 95% CI, − 0.09 to − 0.07, p < 0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.

AB - Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011–2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis. Results and conclusion Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37–3.45%) to 1.93% (95% CI 1.54–2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient − 0.08; 95% CI, − 0.09 to − 0.07, p < 0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.

KW - Anticoagulants

KW - Atrial fibrillation

KW - Cohort studies

KW - Incidence

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=85027528754&partnerID=8YFLogxK

U2 - 10.1016/j.thromres.2017.08.004

DO - 10.1016/j.thromres.2017.08.004

M3 - Article

C2 - 28822239

AN - SCOPUS:85027528754

VL - 158

SP - 44

EP - 48

JO - Thrombosis Research

JF - Thrombosis Research

SN - 1879-2472

ER -