Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors: A systematic review

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Standard

Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors : A systematic review. / Streefkerk, Nina; Fioole, Lisanne C.E.; Beijer, Josien G.M.; Feijen, Elizabeth A.M.; Teepen, Jop C.; Winther, Jeanette F.; Ronckers, Cecile M.; Loonen, Jaqueline J.; van Dulmen-den Broeder, Eline; Skinner, Rod; Hudson, Melissa M.; Tissing, Wim J.E.; Korevaar, Joke C.; Mulder, Renée L.; Kremer, Leontine C.M.

I: Pediatric Blood and Cancer, Vol. 67, Nr. 11, e28611, 01.11.2020.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Harvard

Streefkerk, N, Fioole, LCE, Beijer, JGM, Feijen, EAM, Teepen, JC, Winther, JF, Ronckers, CM, Loonen, JJ, van Dulmen-den Broeder, E, Skinner, R, Hudson, MM, Tissing, WJE, Korevaar, JC, Mulder, RL & Kremer, LCM 2020, 'Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors: A systematic review', Pediatric Blood and Cancer, vol. 67, nr. 11, e28611. https://doi.org/10.1002/pbc.28611

APA

Streefkerk, N., Fioole, L. C. E., Beijer, J. G. M., Feijen, E. A. M., Teepen, J. C., Winther, J. F., Ronckers, C. M., Loonen, J. J., van Dulmen-den Broeder, E., Skinner, R., Hudson, M. M., Tissing, W. J. E., Korevaar, J. C., Mulder, R. L., & Kremer, L. C. M. (2020). Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors: A systematic review. Pediatric Blood and Cancer, 67(11), [e28611]. https://doi.org/10.1002/pbc.28611

CBE

Streefkerk N, Fioole LCE, Beijer JGM, Feijen EAM, Teepen JC, Winther JF, Ronckers CM, Loonen JJ, van Dulmen-den Broeder E, Skinner R, Hudson MM, Tissing WJE, Korevaar JC, Mulder RL, Kremer LCM. 2020. Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors: A systematic review. Pediatric Blood and Cancer. 67(11):Article e28611. https://doi.org/10.1002/pbc.28611

MLA

Vancouver

Author

Streefkerk, Nina ; Fioole, Lisanne C.E. ; Beijer, Josien G.M. ; Feijen, Elizabeth A.M. ; Teepen, Jop C. ; Winther, Jeanette F. ; Ronckers, Cecile M. ; Loonen, Jaqueline J. ; van Dulmen-den Broeder, Eline ; Skinner, Rod ; Hudson, Melissa M. ; Tissing, Wim J.E. ; Korevaar, Joke C. ; Mulder, Renée L. ; Kremer, Leontine C.M. / Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors : A systematic review. I: Pediatric Blood and Cancer. 2020 ; Vol. 67, Nr. 11.

RIS

TY - JOUR

T1 - Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors

T2 - A systematic review

AU - Streefkerk, Nina

AU - Fioole, Lisanne C.E.

AU - Beijer, Josien G.M.

AU - Feijen, Elizabeth A.M.

AU - Teepen, Jop C.

AU - Winther, Jeanette F.

AU - Ronckers, Cecile M.

AU - Loonen, Jaqueline J.

AU - van Dulmen-den Broeder, Eline

AU - Skinner, Rod

AU - Hudson, Melissa M.

AU - Tissing, Wim J.E.

AU - Korevaar, Joke C.

AU - Mulder, Renée L.

AU - Kremer, Leontine C.M.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - We systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation in assessment and definition of the burden of physical long-term morbidity in CCS challenges interpretation, comparison, and pooling data across studies. Global collaboration is needed to standardize assessments and harmonize definitions of long-term physical morbidity and associated outcomes in childhood cancer survivorship research.

AB - We systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation in assessment and definition of the burden of physical long-term morbidity in CCS challenges interpretation, comparison, and pooling data across studies. Global collaboration is needed to standardize assessments and harmonize definitions of long-term physical morbidity and associated outcomes in childhood cancer survivorship research.

KW - childhood cancer survivors

KW - long-term morbidity

KW - outcome assessment

KW - outcome definition

KW - severity grading

U2 - 10.1002/pbc.28611

DO - 10.1002/pbc.28611

M3 - Review article

C2 - 32881287

AN - SCOPUS:85090161887

VL - 67

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

SN - 1545-5017

IS - 11

M1 - e28611

ER -