Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers. / Bengtsson, S; Krogh, Morten; Al-Khalili Szigyarto, C; Uhlen, M; Schedvins, K; Silfversward, C; Linder, S; Auer, G; Alaiya, A; James, Peter.

I: Journal of Proteome Research, Vol. 6, Nr. 4, 2007, s. 1440-1450.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Bengtsson, S, Krogh, M, Al-Khalili Szigyarto, C, Uhlen, M, Schedvins, K, Silfversward, C, Linder, S, Auer, G, Alaiya, A & James, P 2007, 'Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers', Journal of Proteome Research, vol. 6, nr. 4, s. 1440-1450. https://doi.org/10.1021/pr060593y

APA

Bengtsson, S., Krogh, M., Al-Khalili Szigyarto, C., Uhlen, M., Schedvins, K., Silfversward, C., ... James, P. (2007). Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers. Journal of Proteome Research, 6(4), 1440-1450. https://doi.org/10.1021/pr060593y

CBE

Bengtsson S, Krogh M, Al-Khalili Szigyarto C, Uhlen M, Schedvins K, Silfversward C, Linder S, Auer G, Alaiya A, James P. 2007. Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers. Journal of Proteome Research. 6(4):1440-1450. https://doi.org/10.1021/pr060593y

MLA

Vancouver

Bengtsson S, Krogh M, Al-Khalili Szigyarto C, Uhlen M, Schedvins K, Silfversward C et al. Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers. Journal of Proteome Research. 2007;6(4):1440-1450. https://doi.org/10.1021/pr060593y

Author

Bengtsson, S ; Krogh, Morten ; Al-Khalili Szigyarto, C ; Uhlen, M ; Schedvins, K ; Silfversward, C ; Linder, S ; Auer, G ; Alaiya, A ; James, Peter. / Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers. I: Journal of Proteome Research. 2007 ; Vol. 6, Nr. 4. s. 1440-1450.

RIS

TY - JOUR

T1 - Large-Scale Proteomics Analysis of Human Ovarian Cancer for Biomarkers

AU - Bengtsson, S

AU - Krogh, Morten

AU - Al-Khalili Szigyarto, C

AU - Uhlen, M

AU - Schedvins, K

AU - Silfversward, C

AU - Linder, S

AU - Auer, G

AU - Alaiya, A

AU - James, Peter

PY - 2007

Y1 - 2007

N2 - Ovarian cancer is usually found at a late stage when the prognosis is often bad. Relative survival rates decrease with tumor stage or grade, and the 5-year survival rate for women with carcinoma is only 38%. Thus, there is a great need to find biomarkers that can be used to carry out routine screening, especially in high-risk patient groups. Here, we present a large-scale study of 64 tissue samples taken from patients at all stages and show that we can identify statistically valid markers using nonsupervised methods that distinguish between normal, benign, borderline, and malignant tissue. We have identified 217 of the significantly changing protein spots. We are expressing and raising antibodies to 35 of these. Currently, we have validated 5 of these antibodies for use in immunohistochemical analysis using tissue microarrays of healthy and diseased ovarian, as well as other, human tissues.

AB - Ovarian cancer is usually found at a late stage when the prognosis is often bad. Relative survival rates decrease with tumor stage or grade, and the 5-year survival rate for women with carcinoma is only 38%. Thus, there is a great need to find biomarkers that can be used to carry out routine screening, especially in high-risk patient groups. Here, we present a large-scale study of 64 tissue samples taken from patients at all stages and show that we can identify statistically valid markers using nonsupervised methods that distinguish between normal, benign, borderline, and malignant tissue. We have identified 217 of the significantly changing protein spots. We are expressing and raising antibodies to 35 of these. Currently, we have validated 5 of these antibodies for use in immunohistochemical analysis using tissue microarrays of healthy and diseased ovarian, as well as other, human tissues.

U2 - 10.1021/pr060593y

DO - 10.1021/pr060593y

M3 - Article

VL - 6

SP - 1440

EP - 1450

JO - Journal of Proteome Research

JF - Journal of Proteome Research

SN - 1535-3893

IS - 4

ER -