Late cardiac events after childhood cancer: Methodological aspects of the pan-european study pancaresurfup

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. Methods Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data onsymptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected. Results The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient-And general practitioner-based questionnaires. Conclusion The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platformfor future research studies in childhood cancer patients.


  • Elizabeth A M Feijen
  • Anna Font-Gonzalez
  • Elvira C. Van Dalen
  • Helena J H Van Der Pal
  • Raoul C. Reulen
  • David L. Winter
  • Claudia E. Kuehni
  • Riccardo Haupt
  • Daniela Alessi
  • Julianne Byrne
  • Edit Bardi
  • Zsuzsanna Jakab
  • Desiree Grabo
  • Stanislaw Garwicz
  • Momcilo Jankovic
  • Gill A. Levitt
  • Roderick Skinner
  • Lorna Zadravec Zaletel
  • Wim J E Tissing
  • Florent De Vathaire
  • Mike M. Hawkins
  • Leontien C M Kremer
Enheter & grupper
Externa organisationer
  • Academic Medical Center
  • University of Bern
  • Gaslini Children's Hospital
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • Boyne Research Institute
  • Semmelweis University
  • Markusovszky Hospital
  • Universitätsmedizin Mainz
  • University of Milano-Bicocca
  • Great North Children's Hospital
  • University of Newcastle upon Tyne
  • Institute of Oncology, Ljubljana
  • University of Groningen
  • Institut Gustave Roussy
  • University of Birmingham

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Pediatrik
  • Cancer och onkologi
TidskriftPLoS ONE
Utgåva nummer9
StatusPublished - 2016 sep 1
Peer review utfördJa