LEPREL1, a novel ER and Golgi resident member of the Leprecan family.

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LEPREL1, a novel ER and Golgi resident member of the Leprecan family. / Järnum, Sofia; Kjellman, Christian; Darabi, Anna; Nilsson, Ingar; Edvardsen, Klaus; Aman, Pierre.

I: Biochemical and Biophysical Research Communications, Vol. 317, Nr. 2, 2004, s. 342-351.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Järnum, Sofia ; Kjellman, Christian ; Darabi, Anna ; Nilsson, Ingar ; Edvardsen, Klaus ; Aman, Pierre. / LEPREL1, a novel ER and Golgi resident member of the Leprecan family. I: Biochemical and Biophysical Research Communications. 2004 ; Vol. 317, Nr. 2. s. 342-351.

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TY - JOUR

T1 - LEPREL1, a novel ER and Golgi resident member of the Leprecan family.

AU - Järnum, Sofia

AU - Kjellman, Christian

AU - Darabi, Anna

AU - Nilsson, Ingar

AU - Edvardsen, Klaus

AU - Aman, Pierre

N1 - Department affilation moved from v1000588 (Tumour Biology, Malmö) to v1000562 (Department of Translational Medicine) on 2016-01-18 14:39:31.

PY - 2004

Y1 - 2004

N2 - We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adipocytes and neuroendocrine cells of the gastrointestinal epithelium. Muscle tissue contains a specific 6.5 kb transcript and a 200 kDa protein. The 3.4 kb LEPREL1 transcript encodes a 708 amino acid protein containing a signal sequence, four tetratricopeptide repeats (TPRs), a leucine zipper, a P-loop, a prolyl 4-hydroxylase α domain (P4Hα), and a C-terminal KDEL ER-retention motif. LEPREL1 is localized to the ER and Golgi network and over-expressing it affects normal protein disulfide isomerase staining patterns in the ER.

AB - We have identified a novel protein, Leprecan-like 1 (LEPREL1), with profound similarity to the Leprecan family of proteoglycans. The genomic organization of the Leprecan gene family was found to be highly conserved. Expression analysis shows that LEPREL1 is expressed in most tissues as a 3.4 kb transcript encoding an 80 kDa protein. A LEPREL1 specific antibody stains many cell types including adipocytes and neuroendocrine cells of the gastrointestinal epithelium. Muscle tissue contains a specific 6.5 kb transcript and a 200 kDa protein. The 3.4 kb LEPREL1 transcript encodes a 708 amino acid protein containing a signal sequence, four tetratricopeptide repeats (TPRs), a leucine zipper, a P-loop, a prolyl 4-hydroxylase α domain (P4Hα), and a C-terminal KDEL ER-retention motif. LEPREL1 is localized to the ER and Golgi network and over-expressing it affects normal protein disulfide isomerase staining patterns in the ER.

KW - Hydroxylase

KW - TPR

KW - Author Keywords: Protein disulfide isomerase

KW - P4Hα

KW - Liposarcoma

U2 - 10.1016/j.bbrc.2004.03.060

DO - 10.1016/j.bbrc.2004.03.060

M3 - Article

VL - 317

SP - 342

EP - 351

JO - Biochemical and Biophysical Research Communications

T2 - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 1090-2104

IS - 2

ER -