Lesions of the locus coeruleus system aggravate ischemic damage in the rat brain

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The possibility that the noradrenergic locus coeruleus system influences brain damage following ischemia was explored in rats. Bilateral lesions of the locus coeruleus projections to the forebrain aggravated the neuronal necrosis in the hippocampal CAI region and neocortex following complete cerebral ischemia induced by transient cardiac arrest. These findings provide evidence that the postischemic activation of the inhibitory locus coeruleus system could counteract a possible detrimental neuronal hyperexcitation, thereby limiting neuronal necrosis.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Lund University
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)353-358
Antal sidor6
TidskriftNeuroscience Letters
Volym58
Utgåva nummer3
StatusPublished - 1985 aug 5
PublikationskategoriForskning
Peer review utfördJa