Leukemia inhibitory factor null mice: Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Standard

Leukemia inhibitory factor null mice : Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments. / Ekström, Per A R; Kerekes, Nóra; Hökfelt, Tomas.

I: Neuroscience Letters, Vol. 281, Nr. 2-3, 10.03.2000, s. 107-110.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Leukemia inhibitory factor null mice

T2 - Unhampered in vitro outgrowth of sensory axons but reduced stimulatory potential by nerve segments

AU - Ekström, Per A R

AU - Kerekes, Nóra

AU - Hökfelt, Tomas

PY - 2000/3/10

Y1 - 2000/3/10

N2 - Leukemia inhibitory factor (LIF) is locally up-regulated after peripheral nerve injury and may be involved in the subsequent regeneration. Here, adult mice with or without LIF gene deletions were used to study the role of LIF in regeneration. The results show that axonal regeneration in vitro from dorsal root ganglia (DRGs) was unaffected by LIF deletion. However, segments from wild type mice promoted DRG axonal outgrowth better than segments from LIF deleted animals when in vivo-injured sciatic nerve segments were co-cultured with DRGs from normal adult mice. Addition of LIF could not restore the deficit. This suggests that LIF is engaged in the local regulation of regeneration but not in the regenerative events occuring at the cell body level. (C) 2000 Elsevier Science Ireland Ltd.

AB - Leukemia inhibitory factor (LIF) is locally up-regulated after peripheral nerve injury and may be involved in the subsequent regeneration. Here, adult mice with or without LIF gene deletions were used to study the role of LIF in regeneration. The results show that axonal regeneration in vitro from dorsal root ganglia (DRGs) was unaffected by LIF deletion. However, segments from wild type mice promoted DRG axonal outgrowth better than segments from LIF deleted animals when in vivo-injured sciatic nerve segments were co-cultured with DRGs from normal adult mice. Addition of LIF could not restore the deficit. This suggests that LIF is engaged in the local regulation of regeneration but not in the regenerative events occuring at the cell body level. (C) 2000 Elsevier Science Ireland Ltd.

KW - Conditioning lesion

KW - Dorsal root ganglia

KW - Knock-out

KW - Neurite outgrowth

KW - Regeneration

KW - Stimulation

UR - http://www.scopus.com/inward/record.url?scp=0033999591&partnerID=8YFLogxK

U2 - 10.1016/S0304-3940(00)00816-8

DO - 10.1016/S0304-3940(00)00816-8

M3 - Article

C2 - 10704754

AN - SCOPUS:0033999591

VL - 281

SP - 107

EP - 110

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2-3

ER -