Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In our study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake.


  • Sabine Naudin
  • Kuanrong Li
  • Tristan Jaouen
  • Nada Assi
  • Cecilie Kyrø
  • Anne Tjønneland
  • Kim Overvad
  • Marie Christine Boutron-Ruault
  • Vinciane Rebours
  • Anne Laure Védié
  • Heiner Boeing
  • Rudolf Kaaks
  • Verena Katzke
  • Christina Bamia
  • Androniki Naska
  • Antonia Trichopoulou
  • Franco Berrino
  • Giovanna Tagliabue
  • Domenico Palli
  • Salvatore Panico
  • Rosario Tumino
  • Carlotta Sacerdote
  • Petra H. Peeters
  • Bas Bueno-de-Mesquita
  • Elisabete Weiderpass Vainio
  • Inger Torhild Gram
  • Guri Skeie
  • Maria Dolores Chirlaque
  • Miguel Rodríguez-Barranco
  • Aurelio Barricarte
  • Jose Ramón Quirós
  • Miren Dorronsoro
  • Ingegerd Johansson
  • Malin Sund
  • Kathryn E. Bradbury
  • Nick Wareham
  • Elio Riboli
  • Marc Gunter
  • Paul Brennan
  • Eric J. Duell
  • Pietro Ferrari
Enheter & grupper
Externa organisationer
  • International Agency for Research on Cancer, World Health Organization
  • Danish Cancer Society Research Center
  • Aarhus University
  • German Institute of Human Nutrition
  • German Cancer Research Centre
  • Istituto Nazionale dei Tumori
  • Cancer Research and Prevention Institute
  • UiT The Arctic University of Norway, Tromsø
  • Umeå University
  • University of Cambridge
  • Imperial College London
  • Bellvitge Biomedical Research Institute
  • University of Oxford
  • Public Health Directorate
  • CIBER Epidemiology and Public Health (CIBERESP)
  • Health Research Institute of Navarra (IDISNA)
  • Navara Public Health Institute
  • University of Granada
  • Murcia Regional Health Council
  • University of Murcia
  • Cancer Registry of Norway Institute of Population-Based Cancer Research
  • Karolinska Institute
  • Folkhälsans forskningscentrum
  • National Institute for Public Health and the Environment (RIVM)
  • University of Malaya
  • University Medical Center Utrecht
  • Citta' della Salute e della Scienza Hospital-University of Turin
  • Civic and M.P.Arezzo Hospital
  • University of Naples Federico II

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Sidor (från-till)801-812
TidskriftInternational Journal of Cancer
Utgåva nummer4
Tidigt onlinedatum2018 mar 30
StatusPublished - 2018
Peer review utfördJa