Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.

Detaljer

Författare
  • Ming-Mei Shang
  • Husain A Talukdar
  • Jennifer J Hofmann
  • Colin Niaudet
  • Hassan Foroughi Asl
  • Rajeev K Jain
  • Aranzazu Rossignoli
  • Cecilia Cedergren
  • Angela Silveira
  • Bruna Gigante
  • Karin Leander
  • Ulf de Faire
  • Anders Hamsten
  • Arno Ruusalepp
  • Torbjörn Ivert
  • Tom Michoel
  • Eric E Schadt
  • Christer Betsholtz
  • Josefin Skogsberg
  • Johan L M Björkegren
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
Originalspråkengelska
Sidor (från-till)2068-2077
TidskriftArteriosclerosis, Thrombosis and Vascular Biology
Volym34
Utgivningsnummer9
StatusPublished - 2014
PublikationskategoriForskning
Peer review utfördJa