Limited protective effect of the CCR5 Delta 32/CCR5 Delta 32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in similar to2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated with a CD4 cell-stimulating drug, tucaresol. Age-related differences in disease progression rate and survival time were seen for CCR5/CCR5 patients. Surprisingly, no protective effect of the CCR5/CCR5Delta32 genotype on disease progression or survival was seen for children but was evident for adults. Age group-related immunologic differences might explain this variation, and transmission route and/or viral phenotype variation within donor virus may be related to the limited protection of the CCR5Delta32/ CCR5Delta32 genotype. Sequence comparisons indicate that X4 virus can be selected in vivo due to either absence of CCR5 receptors or relative increase of CXCR4 receptors.

Detaljer

Författare
  • AKN Iversen
  • CB Christiansen
  • J Attermann
  • J Eugen-Olsen
  • S Schulman
  • Erik Berntorp
  • J Ingerslev
  • L Fugger
  • E Scheibel
  • Lilian Tengborn
  • J Gerstoft
  • E Dickmeiss
  • A Svejgaard
  • P Skinhoj
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin
Originalspråkengelska
Sidor (från-till)215-225
TidskriftJournal of Infectious Diseases
Volym187
Utgåva nummer2
StatusPublished - 2003
PublikationskategoriForskning
Peer review utfördJa