Lin28b controls a neonatal to adult switch in B cell positive selection

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title = "Lin28b controls a neonatal to adult switch in B cell positive selection",
abstract = "The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5+ immature B cells in particular. Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19-/- adult mice. Thus, the temporally restricted expression of Lin28b relaxes the rules for B cell selection during ontogeny by modulating tonic signaling. We propose that this neonatal mode of B cell selection represents a cell-intrinsic cue to accelerate the de novo establishment of the adaptive immune system and incorporate a layer of natural antibody-mediated immunity throughout life.",
author = "Stijn Vanhee and Hugo {\AA}kerstrand and Kristiansen, {Trine Ahn} and Sebak Datta and Giorgia Montano and Stefano Vergani and Stefan Lang and Jonas Ungerb{\"a}ck and Alexander Doyle and Karin Olsson and Giulia Beneventi and Jensen, {Christina T.} and Cristian Bellodi and Shamit Soneji and Mikael Sigvardsson and Gyllenb{\"a}ck, {Elin Jaensson} and Joan Yuan",
year = "2019",
doi = "10.1126/sciimmunol.aax4453",
language = "English",
volume = "4",
journal = "Science Immunology",
issn = "2470-9468",
publisher = "American Association for the Advancement of Science",
number = "39",