Lin28b controls a neonatal to adult switch in B cell positive selection

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Lin28b controls a neonatal to adult switch in B cell positive selection. / Vanhee, Stijn; Åkerstrand, Hugo; Kristiansen, Trine Ahn; Datta, Sebak; Montano, Giorgia; Vergani, Stefano; Lang, Stefan; Ungerbäck, Jonas; Doyle, Alexander; Olsson, Karin; Beneventi, Giulia; Jensen, Christina T.; Bellodi, Cristian; Soneji, Shamit; Sigvardsson, Mikael; Gyllenbäck, Elin Jaensson; Yuan, Joan.

I: Science Immunology, Vol. 4, Nr. 39, eaax4453, 2019.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift

Harvard

Vanhee, S, Åkerstrand, H, Kristiansen, TA, Datta, S, Montano, G, Vergani, S, Lang, S, Ungerbäck, J, Doyle, A, Olsson, K, Beneventi, G, Jensen, CT, Bellodi, C, Soneji, S, Sigvardsson, M, Gyllenbäck, EJ & Yuan, J 2019, 'Lin28b controls a neonatal to adult switch in B cell positive selection', Science Immunology, vol. 4, nr. 39, eaax4453. https://doi.org/10.1126/sciimmunol.aax4453

APA

Vanhee, S., Åkerstrand, H., Kristiansen, T. A., Datta, S., Montano, G., Vergani, S., Lang, S., Ungerbäck, J., Doyle, A., Olsson, K., Beneventi, G., Jensen, C. T., Bellodi, C., Soneji, S., Sigvardsson, M., Gyllenbäck, E. J., & Yuan, J. (2019). Lin28b controls a neonatal to adult switch in B cell positive selection. Science Immunology, 4(39), [eaax4453]. https://doi.org/10.1126/sciimmunol.aax4453

CBE

Vanhee S, Åkerstrand H, Kristiansen TA, Datta S, Montano G, Vergani S, Lang S, Ungerbäck J, Doyle A, Olsson K, Beneventi G, Jensen CT, Bellodi C, Soneji S, Sigvardsson M, Gyllenbäck EJ, Yuan J. 2019. Lin28b controls a neonatal to adult switch in B cell positive selection. Science Immunology. 4(39):Article eaax4453. https://doi.org/10.1126/sciimmunol.aax4453

MLA

Vanhee, Stijn et al. "Lin28b controls a neonatal to adult switch in B cell positive selection". Science Immunology. 2019. 4(39). https://doi.org/10.1126/sciimmunol.aax4453

Vancouver

Vanhee S, Åkerstrand H, Kristiansen TA, Datta S, Montano G, Vergani S et al. Lin28b controls a neonatal to adult switch in B cell positive selection. Science Immunology. 2019;4(39). eaax4453. https://doi.org/10.1126/sciimmunol.aax4453

Author

Vanhee, Stijn ; Åkerstrand, Hugo ; Kristiansen, Trine Ahn ; Datta, Sebak ; Montano, Giorgia ; Vergani, Stefano ; Lang, Stefan ; Ungerbäck, Jonas ; Doyle, Alexander ; Olsson, Karin ; Beneventi, Giulia ; Jensen, Christina T. ; Bellodi, Cristian ; Soneji, Shamit ; Sigvardsson, Mikael ; Gyllenbäck, Elin Jaensson ; Yuan, Joan. / Lin28b controls a neonatal to adult switch in B cell positive selection. I: Science Immunology. 2019 ; Vol. 4, Nr. 39.

RIS

TY - JOUR

T1 - Lin28b controls a neonatal to adult switch in B cell positive selection

AU - Vanhee, Stijn

AU - Åkerstrand, Hugo

AU - Kristiansen, Trine Ahn

AU - Datta, Sebak

AU - Montano, Giorgia

AU - Vergani, Stefano

AU - Lang, Stefan

AU - Ungerbäck, Jonas

AU - Doyle, Alexander

AU - Olsson, Karin

AU - Beneventi, Giulia

AU - Jensen, Christina T.

AU - Bellodi, Cristian

AU - Soneji, Shamit

AU - Sigvardsson, Mikael

AU - Gyllenbäck, Elin Jaensson

AU - Yuan, Joan

PY - 2019

Y1 - 2019

N2 - The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5+ immature B cells in particular. Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19-/- adult mice. Thus, the temporally restricted expression of Lin28b relaxes the rules for B cell selection during ontogeny by modulating tonic signaling. We propose that this neonatal mode of B cell selection represents a cell-intrinsic cue to accelerate the de novo establishment of the adaptive immune system and incorporate a layer of natural antibody-mediated immunity throughout life.

AB - The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function of developmental time by exploiting a link between CD5 surface levels and the natural occurrence of self-reactive B cell receptors (BCRs) in BCR wild-type mice. We show that the heterochronic RNA binding protein Lin28b potentiates a neonatal mode of B cell selection characterized by enhanced overall positive selection in general and the developmental progression of CD5+ immature B cells in particular. Lin28b achieves this by amplifying the CD19/PI3K/c-Myc positive feedback loop, and ectopic Lin28b expression restores both positive selection and mature B cell numbers in CD19-/- adult mice. Thus, the temporally restricted expression of Lin28b relaxes the rules for B cell selection during ontogeny by modulating tonic signaling. We propose that this neonatal mode of B cell selection represents a cell-intrinsic cue to accelerate the de novo establishment of the adaptive immune system and incorporate a layer of natural antibody-mediated immunity throughout life.

U2 - 10.1126/sciimmunol.aax4453

DO - 10.1126/sciimmunol.aax4453

M3 - Article

C2 - 31562190

AN - SCOPUS:85072704797

VL - 4

JO - Science Immunology

JF - Science Immunology

SN - 2470-9468

IS - 39

M1 - eaax4453

ER -