Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.

Detaljer

Författare
Externa organisationer
  • Lund University
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicin och hälsovetenskap
Originalspråkengelska
Sidor (från-till)553-556
Antal sidor4
TidskriftScandinavian Journal of Clinical & Laboratory Investigation
Volym48
Utgåva nummer6
StatusPublished - 1988 okt 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa