Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes

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Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes. / Jensen, Elmo; Florén, Claes-Henrik; Nilsson, Åke.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Vol. 48, Nr. 6, 01.10.1988, s. 553-556.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes

AU - Jensen, Elmo

AU - Florén, Claes-Henrik

AU - Nilsson, Åke

PY - 1988/10/1

Y1 - 1988/10/1

N2 - Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.

AB - Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.

U2 - 10.3109/00365518809085772

DO - 10.3109/00365518809085772

M3 - Article

VL - 48

SP - 553

EP - 556

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 1502-7686

IS - 6

ER -