Loss of the tumor suppressor gene AIP mediates the browning of human brown fat tumors

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Human brown fat tumors (hibernomas) display concomitant loss of the tumor suppressor genes MEN1 and AIP. In the present study, we hypothesized that the brown fat phenotype is attributed to these mutations. Accordingly, we demonstrate that silencing of AIP in human brown preadipocytic and white fat cell lines results in the induction of the brown fat marker UCP1. In human adipocytic tumors, loss of MEN1 was found both in white (one out of 51 lipomas) and brown fat tumors. In contrast, concurrent loss of AIP was always accompanied by a brown fat morphology. We conclude that this white-to-brown phenotype switch in brown fat tumors is mediated by the loss of AIP.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Regional Laboratories Region Skåne
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicinsk genetik
  • Cancer och onkologi

Nyckelord

Originalspråkengelska
Sidor (från-till)160-164
TidskriftJournal of Pathology
Volym243
Utgivningsnummer2
StatusPublished - 2017 okt
PublikationskategoriForskning
Peer review utfördJa