Lung function and pulmonary vascular resistance are not associated in 6-year-old children born extremely preterm

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Aim: Children born preterm are at increased risk of reduced lung function. The aim was to test whether lung function was associated with pulmonary vascular resistance. Methods: Participants were recruited from a population-based cohort born in 2004-2007. Lung function was assessed with spirometry after administration of a beta2-agonist. Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were determined. Estimations of pulmonary vascular resistance, arterial dimensions, right ventricular wall thickness, sphericity, and systolic (TAPSE) and diastolic functions were performed with echocardiography. Adjusted regression analyses were used to study associations. Results: Sixty-six children (33 boys) born at 22-26 weeks of gestational age (birthweights 460-1134 g) were assessed at a mean age of 6.7 years. Despite large variations in lung function with FVC z-scores ranging from −4.6 to +2.8, there were no associations between lung function and pulmonary arterial pressure, right ventricular structure or function. Children with higher FVC z-scores (r =.52, β =.55 mm, P =.015) and higher FEV1 z-scores (r =.58, β =.73 mm, P =.001) exhibited larger pulmonary arteries. Conclusion: In children born extremely preterm, lung function was not associated with pulmonary vascular resistance. Routine echocardiographic evaluation of extremely preterm children may not be indicated at age 6.5 years.


  • Lilly Ann Mohlkert
  • Gunnar Sjöberg
  • Annika Rydberg
  • Cecilia Pegelow Halvorsen
  • Ellen Tufvesson
  • Jenny Hallberg
  • Magnus Domellöf
  • Mikael Norman
Enheter & grupper
Externa organisationer
  • Karolinska Institute
  • Södersjukhuset
  • Umeå University
  • Karolinska University Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi
  • Pediatrik


Sidor (från-till)746-753
Antal sidor8
TidskriftActa Paediatrica, International Journal of Paediatrics
Utgåva nummer4
Tidigt onlinedatum2019 sep 26
StatusPublished - 2020 apr
Peer review utfördJa