Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.

Detaljer

Författare
  • Joana Carrelha
  • Michael Lutteropp
  • Sidinh Luc
  • Joanna C A Green
  • Emanuele Azzoni
  • Petter S Woll
  • Adam J Mead
  • Gemma Swiers
  • Elisa Gomez Perdiguero
  • Iain C Macaulay
  • Luca Melchiori
  • Tiago C Luis
  • Shabnam Kharazi
  • Tiphaine Bouriez-Jones
  • Qiaolin Deng
  • Annica Pontén
  • Deborah Atkinson
  • Frederic Geissmann
  • Isabelle Godin
  • Rickard Sandberg
  • Marella F T R de Bruijn
  • Sten Eirik W Jacobsen
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cellbiologi
Originalspråkengelska
Sidor (från-till)535-548
TidskriftCell Stem Cell
Volym13
Utgivningsnummer5
StatusPublished - 2013
PublikationskategoriForskning
Peer review utfördJa