Magnesium status in Crohns disease as evaluated by intracellular analysis and intravenous magnesium infusion

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Abstract

The magnesium status was evaluated in 30 subjects with Crohn's disease and in 30 controls. Subjects with Crohn's disease had lower concentrations of magnesium in muscle biopsy specimens (p less than 0.001), mononuclear cells (p less than 0.05), and in urine collected during 24 h (p less than 0.001) as compared with controls. After intravenous infusion of 60 mmol magnesium and 80 mmol potassium to 17 subjects with Crohn's disease a significant increase in concentrations of magnesium in muscle specimens (p less than 0.05), mononuclear cells (p less than 0.01), and plasma (p less than 0.01) was noted. The retention of intravenously infused magnesium was significantly higher in subjects with Crohn's disease than in 11 healthy controls (p less than 0.001) and was inversely correlated with the content of magnesium in muscle specimens (r = -0.52; p less than 0.05). The implication of these findings is that analysis of magnesium in muscle specimens and estimation of magnesium retention during an intravenous magnesium infusion are useful to confirm a suspected magnesium deficiency.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Originalspråksvenska
Artikelnummer3399827
Sidor (från-till)555-61
TidskriftScandinavian Journal of Gastroenterology
Volym23
Utgivningsnummer5
StatusPublished - 1988
PublikationskategoriForskning
Peer review utfördJa