Malignancies In Giant Cell Arteritis: A Population-Based Cohort Study

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Abstract

OBJECTIVE: To investigate the risk of cancer in patients with biopsy-proven giant cell arteritis (GCA) from a defined population in southern Sweden.

METHODS: The study cohort consisted of 830 patients (mean age at GCA diagnosis was 76.3 years, 74 % women) diagnosed with biopsy-proven GCA between 1997 and 2010. Temporal artery biopsy results were retrieved from a regional database and reviewed to ascertain GCA diagnosis. The cohort was linked to the Swedish Cancer Registry. The patients were followed from GCA diagnosis until death or December 31, 2013. Incident malignancies registered after GCA diagnosis were studied. Based on data on the first malignancy in each organ system, age- and sex standardized incidence ratios (SIR) with 95 % confidence intervals (CI) were calculated compared to the background population.

RESULTS: 107 patients (13%) were diagnosed with a total of 118 new malignancies after the onset of GCA. The overall risk for cancer after the GCA diagnosis was not increased (SIR 0.98; 95% CI 0.81 - 1.17). However, there was an increased risk for myeloid leukemia (2.31; 95% CI 1.06 - 4.39) and a reduced risk for breast cancer (0.33; 95% CI 0.12 - 0.72) and upper gastrointestinal tract cancer (0.16; 95% 0.004- 0.91). Rates of other site-specific cancers were not different from expected.

CONCLUSION: In this Swedish population-based cohort of GCA, the overall risk for cancer was not increased compared to the background population. However, there was an increased risk for leukemia and a decreased risk for breast and upper gastrointestinal tract cancer.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reumatologi och inflammation
Originalspråkengelska
TidskriftJournal of Rheumatology
Volym46
Utgivningsnummer7
Tidigt onlinedatum2019 jun 1
StatusPublished - 2019 jul 1
PublikationskategoriForskning
Peer review utfördJa