Malignant hyperthermia, a Scandinavian update.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Malignant Hyperthermia (MH) is a rare pharmacogenetic disorder, triggered by halogenated anesthetics and/or succinylcholine. In susceptible individuals, these drugs can activate an explosive life threatening clinical reaction. Leading symptoms are hypercarbia, muscle rigidity, and metabolic acidosis. MH is inherited in an autosomal-dominant manner and linked to mutations in the large ryanodine 1 gene (RYR1) gene in the majority of cases. Very few MH patients have been found to carry mutations in the CACNA1S gene.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Anestesi och intensivvård
Originalspråkengelska
Sidor (från-till)951-961
TidskriftActa Anaesthesiologica Scandinavica
Volym59
Utgivningsnummer8
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa