Management and outcomes following emergency surgery for traumatic brain injury – A multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study)

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Introduction: Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. Despite this, considerable geographical differences have been reported in the care of TBI patients. On this background, we aim to provide a comprehensive international picture of the epidemiological characteristics, management and outcomes of patients undergoing emergency surgery for traumatic brain injury (TBI) worldwide. Methods and analysis: The Global Neurotrauma Outcomes Study (GNOS) is a multi-centre, international, prospective observational cohort study. Any unit performing emergency surgery for TBI worldwide will be eligible to participate. All TBI patients who receive emergency surgery in any given consecutive 30-day period beginning between 1st of November 2018 and 31st of December 2019 in a given participating unit will be included. Data will be collected via a secure online platform in anonymised form. The primary outcome measures for the study will be 14-day mortality (or survival to hospital discharge, whichever comes first). Final day of data collection for the primary outcome measure is February 13th. Secondary outcome measures include return to theatre and surgical site infection. Ethics and dissemination: This project will not affect clinical practice and has been classified as clinical audit following research ethics review. Access to source data will be made available to collaborators through national or international anonymised datasets on request and after review of the scientific validity of the proposed analysis by the central study team.


  • David Clark
  • Alexis Joannides
  • Omar Ibrahim Abdallah
  • Amos Olufemi Adeleye
  • Abdul Hafid Bajamal
  • Tom Bashford
  • Arnold Bhebhe
  • Hagos Biluts
  • Natalia Budohoska
  • Karol Budohoski
  • Iype Cherian
  • Rocio Fernandez Mendez
  • Tony Figaji
  • Deepak Kumar Gupta
  • Corrado Iaccarino
  • Ali Ilunga
  • Mathew Joseph
  • Tariq Khan
  • Tsegazeab Laeke
  • Vicknes Waran
  • Kee Park
  • Gail Rosseau
  • Andres Rubiano
  • Youssuf Saleh
  • Hamisi K. Shabani
  • Brandon Smith
  • Kachinga Sichizya
  • Manoj Tewari
  • Abenezer Tirsit
  • Myat Thu
  • Manjul Tripathi
  • Rikin Trivedi
  • Sofia Villar
  • Indira Devi Bhagavatula
  • Franco Servadei
  • David Menon
  • Angelos Kolias
  • Peter Hutchinson
Enheter & grupper
Externa organisationer
  • University of Cambridge
  • University Teaching Hospital Lusaka
  • University City College Hospital, Ibadan
  • Dr. Soetomo Hospital
  • Addis Ababa University
  • Nobel Medical College Teaching Hospital
  • University of Cape Town
  • All India Institute of Medical Sciences
  • Parma University Hospital
  • Christian Medical College & Hospital
  • North West General Hospital & Research Center
  • University of Malaya
  • El Bosque University
  • University of Oxford
  • Postgraduate Institute of Medical Education and Research
  • Yangon General Hospital
  • Medical Research Council Biostatistics Unit
  • National Institute of Mental Health and Neurosciences, Bangalore
  • Humanitas University
  • Sohag University Hospital
  • Skåne University Hospital
  • Harvard University
  • George Washington University
  • Muhimbili University of Health and Allied Sciences
  • Tikur Anbessa Specialized Hospital

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kirurgi
  • Neurologi


Sidor (från-till)1-7
Antal sidor7
TidskriftInternational Journal of Surgery Protocols
StatusPublished - 2020
Peer review utfördJa