Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Bibtex

@article{ecd585bc0508462687ed26012a6ad213,
title = "Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II",
abstract = "In mitosis, the Greatwall kinase (called microtubuleassociated serine/threonine kinase like [Mastl] in mammals)is essential for prometaphase entry or progression by suppressing protein phosphatase 2A (PP2A) activity. PP2A suppression in turn leads to high levels of Cdk1 substrate phosphorylation. We have used a mouse model with an oocyte-specific deletion of Mastl to show that Mastl-null oocytes resume meiosis I and reach metaphase I normally but that the onset and completion of anaphase I are delayed. Moreover, after the completion of meiosis I, Mastl-null oocytes failed to enter meiosis II (MII) because they reassembled a nuclear structure containing decondensed chromatin. Our results show that Mastl is required for the timely activation of anaphase-promoting complex/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 activity that is needed for the entry into MII in mouse oocytes.",
author = "Deepak Adhikari and Diril, {M. Kasim} and Kiran Busayavalasa and Sanjiv Risal and Shoma Nakagawa and Rebecca Lindkvist and Yan Shen and Vincenzo Coppola and Lino Tessarollo and Kudo, {Nobuaki R.} and Philipp Kaldis and Kui Liu",
year = "2014",
month = sep,
day = "29",
doi = "10.1083/jcb.201406033",
language = "English",
volume = "206",
pages = "843--853",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "7",

}